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To get to the Bronx Zoo by subway, you would take the 2 train. The Bronx Zoo is located near the Bronx Park stop on the 2 train line. This route is a direct and convenient way to reach the zoo using public transportation in New York City.

The other options (4, 6, and 3) do not directly serve the Bronx Zoo and would require additional transfers or walking distance, making the 2 train the most suitable choice for this particular destination.